Japan has developed an organic amplification circuit that can be implanted into the human body for a long time

Japan has developed an organic amplification circuit that can be implanted into the human body for a long time

(a) Enlarged view of the gel electrode, (b) Photo of the slice-type biosignal amplifying circuit, (c) Schematic sectional view


The above figure shows the electrocardiogram of the rat before signal amplification. The following figure shows the electrocardiogram of the rat amplified by the signal amplification circuit.

On April 29, 2016, the University of Tokyo and Osaka University announced that they have developed organically-magnetized electrodes that are biocompatible and soft in texture. It is characterized by long-term implantation of the human body. Using this circuit chip can stably measure a weak ECG signal and successfully determine the location of the heart. It is expected to be widely used as a new generation of components.

The new gel material developed this time was prepared by uniformly mixing single-walled carbon nanotubes in a hydrogel called polyrotaxane. Because carbon nanotubes have a large surface area and are easy to aggregate into bundles, they are difficult to disperse evenly in the gel. Researchers have adopted the technique of separating carbon nanotubes by using ionic liquids, making nanotubes uniformly dispersed in gels. The electrical conductivity of the gel is achieved.

This gel has a Young's modulus of 10 kPa, a soft and flexible texture, and an admittance of 100 mS/cm2. The current in the flexible material is the best. In the frequency range of 10 to 106 Hz, the admittance is basically the same. In addition, the results of the biocompatibility evaluation performed according to ISO10993-5 (Cytotoxicity Test) and ISO10993-6 (Long-term Implanted Human Test) show that this circuit is compared with metal electrodes used in past implantable electronic devices. Tablets have minimal inflammation.

The researchers integrated this gel electrode with an amplifying circuit of an organic transistor configured on a 1 μm-thick ultrathin polymer film, and developed a chip biopotential sensor equipped with an amplifying circuit. An amplifying circuit can amplify the signal by a factor of 200. The magnification in the 100 Hz band is 100 times and the magnification in 1000 Hz is more than 10 times. The amplifying circuit is arranged in an 8x8 grid pattern at an interval of 6mm. The patch biopotential sensor is attached to the heart of rats suffering from heart disease, abnormal electrocardiogram and normal electrocardiogram caused by ischemia can be detected, and the location of myocardial infarction can be accurately determined.

The bio-electricity measuring sensor of the chip type has very little inflammatory response directly attached to the internal organs, and can minimize the burden on the internal organs that are damaged due to the disease during the inspection. If the sensor is attached to the heart during surgery, the location of the myocardial infarction can be inferred with high precision, which can help the doctor to determine the surgical plan on the spot. In the future, it is also expected that the human body will be implanted for a long time so that the disease can be discovered and treated as soon as possible.

This research is part of the strategic creation research promotion business of the Japan Science and Technology Agency (JST). The research results were published in Nature Communications on April 29th. (Special Contributor: Kudosuke)

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